Ravi Vijayvargia

FACULTY OF SCIENCE >> Department of Bio-Chemistry
Designation : Assistant Professor
Qualification : M.Sc. in Bio-Chemistry (M.S. University of Baroda, 1997) Ph.D. in Biotechnology (NCCS, Pune, 2004)
Phone Nos : 912652795594
Email :
Experience : (i) Post-Doctoral research at University of Medicine and Dentistry of New Jersey, Piscataway, NJ, U.S.A from 2004-2009 (ii) Post-Doctoral research at Massachusetts General Hospital-Harvard Medical School, Boston, U.S.A from 2009 to 2013
Areas of Interest : Research interests: (i) Impact of polyQ expansion on Huntingtin structure and function (ii) To determine prevalence of Huntington's Disease in Gujarat (iii) Post Translational modifications as Therapeutic targets in Huntington's Disease
Ravi  Vijayvargia

Detailed CV

Name:  Dr. Ravi Vijayvargia
Designation: Assistant Professor
Contact: ratipu@yahoo.com, +91-265-2795594 ext. 225, 09530079180
Academic background:
Year Degree Field of Study Institution
2004 Ph.D Biotechnology
( Dr M.V Krishnasastry)
National Center for Cell Science,
Pune University, Pune, India
1997 M.Sc (Master of
Biochemistry Maharaja Sayajirao University of
Baroda, Vadodara, India
1995 B.Sc (Bachelor of Science) Botany, Zoology
and Chemistry
Mohan Lal Sukhadia
University, Udaipur, India
Professional experience:
Year(s) Title Speciality/Discipline Institution
2013 onwards Assistant Professor Biochemistry M.S. University of Baroda,
Vadodara, Gujarat
2009- 2013 Research Fellow Huntingtin Research
PI- Dr Marcy E. MacDonald
Massachusetts General Hospital  
2006-2009 Postdoctoral Appointee Diabetes Research
PI- Dr. Hong Ruan
University of Medicine and
Dentistry of New Jersey
2004-2006 Postdoctoral Appointee Cancer Research
PI- Dr Joseph D. Fondell
University of Medicine and
Dentistry of New Jersey
Research interests:
  • Impact of polyQ expansion on Huntingtin structure and function
  • To determine prevalence of Huntington's Disease in Gujarat
  • Post Translational modifications as Therapeutic targets in Huntington's Disease
Supervised master degrees: One
List of recent publications: 
  • Vijayvargia R, Epand R, Leitner A, Jung TY, Shin B, Jung R, Lloret A, Atwal RS, Lee H, Lee JM,  Aebersold R, Hebert H, Song JJ and Seong IS (2016) Huntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function. eLife 2016;10.7554/eLife.11184; DOI: http://dx.doi.org/10.7554/eLife.11184
  • Biagioli M, Ferrari F, Mendenhall EM, Zhang Y, Erdin S, Vijayvargia R, Vallabh SM, Solomos N, Manavalan P, Ragavendran A, Ozsolak F, Lee JM, Talkowski ME, Gusella JF, Macdonald ME, Park PJ, Seong IS (2015) Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation. Hum Mol Genet. 24(9):2442-57
  • Vijayvargia R, Mann K, Weiss HR, Pownall HJ and Ruan H (2010) JNK deficiency enhances Fatty acid utilization and diverts glucose from oxidation to glycogen storage in cultured  myotubes. Obesity (Silver Spring) 18(9):1701-1709.
  • Rozo AV, Vijayvargia R, Weiss H and Ruan H (2008) Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in adipocytes. Diabetologia, 51(8):1493-504.
  • Belakavadi, M., Pandey, P.K., Vijayvargia, R. and Fondell J.D. (2008). Nuclear hormone Activation of MAPK signaling activates MED1/TRAP220 and potentiates nuclear receptor dependent  transcription.  Mol. Cell. Biol, 28(12): 3932-42.
  • Vijayvargia R, May M and Fondell J.D. (2007) An essential co regulatory role for the Mediator complex in prostate cancer cell growth. Cancer Res., 67(9): 4034-4041.
  • Vijayvargia R, Kaur S, Krishnasastry M.V.(2004) α-Hemolysin induced Dephosphorylation of EGF  receptor of A431 cells is carried out by rPTPσ. Biochem Biophys Res Commun. 325: 344-352.
  • Vijayvargia R, Kaur S, Sangha N, Sahasrabuddhe A.A, Surolia I, Shouche Y, Krishnasastry M.V. (2004) Assembly of alpha-hemolysin on A431 cells leads to clustering of Caveolin-1. Biochem Biophys Res Commun, 324(3): 1124-1129.
  • Vijayvargia R, Suresh C.G, Krishnasastry M.V.(2004) Functional form of Caveolin-1 is necessary for the assembly of alpha-hemolysin. Biochem Biophys Res Commun, 324(3): 1130-1136.
  • Pany S, Vijayvargia R, Krishnasastry M.V. (2004) Caveolin-1 binding motif of alpha-hemolysin: its role in stability and pore formation. Biochem Biophys Res Commun, 322(1): 29-36.
  • Vijayvargia R and Biswas I (2002) MutS2 family protein from Pyrococcus furiosus. Curr Microbiol. 44(3): 224-228.
  • Biswas I and Vijayvargia R (2000) Heteroduplex DNA and ATP induced conformational changes of a MutS mismatch repair protein from Thermus aquaticus. Biochem J. 347(3): 781-784.
  •  Vijayvargia R, Kumar M, Gupta S (2000) Hypoglycemic effect of aqueous extract of Enicstemma Littorale Blume (Chhota Chirayata)on alloxan induced diabetes mellitus in rats. Indian J Exp Biol. 38(8): 781-784.
Courses being taught during 2013-2014:
Biochemical Toxicology, Metabolism, Neurochemistry, Human Genetics
Protein purification practical
Detailed Curriculum Vitae: see link
Any other relevant information:           
Fellowships and Awards
Year Name of Scholarship/Award Awarding Organization Achievement for which
2006 Gallo Award New Jersey state commission on cancer research (NJCCR) and The Cancer institute of New Jersey  (CINJ) For excellence in
cancer research
1998 Junior Research Fellowship (JRF) National Centre for Cell Science, DBT, Pune India Clearing National entrance test
1998 Junior Research Fellowship (JRF) UGC-CSIR, India Clearing the National
Eligibility Test (NET)


25-11-2016 17:40:08