Dr. R. Begum

FACULTY OF SCIENCE >> Department of Bio-Chemistry
 
Designation : Professor
Qualification : M.Sc., Ph.D. in Biochemistry (Aligarh Muslim University), 1986
Phone Nos : 912652795594
Email :
Experience : Date of Joining : 19/12/1985 Position : Professor
Areas of Interest : (1)Teaching: Molecular Biology and Genetic Engineering (2)Research: Protein chemistry and Molecular Biology
 
Dr. R. Begum

Detailed CV

Dr. Rasheedunnisa Begum

Contact:rasheedunnisab@yahoo.co.in, +91-265-2795594

Academic background:
 
  • M.Sc. (S.V. University, Tirupati)
  • Ph.D. (Aligarh Muslim University, Aligarh)

Professional experience:
  • Professor from June, 2006 till date (M.S. University of Baroda)
  • Reader from June, 1998 to June, 2006 (M.S. University of Baroda)
  • Senior Lecturer from Dec. 1990 to June, 1998 (M.S. University of Baroda)
  • Lecturer from Dec.1985 to Dec. 1990 (M.S. University of Baroda)
  • DBT National Associate from June, 1997 to June, 1999 (NII, New Delhi) 

Research interests:
  • Molecular aspects of Cell Death and involvement of PARP in D. discoideum Development. 
  • Biochemical, Cellular and Genetic basis of Vitiligo.
  •  Molecular Genetics of Human Diseases.

Supervised doctoral theses and masters degrees:
  Awarded Working
Ph.D. 9 10
M.Phil. 3 Nil
M.Sc./M.Pharm/B.Tech dissertations 82 3


List of recent publications:
  • Mir H, Alex T, Rajawat J, Kadam A and Begum R (2015) Response of Dictyostelium discoideum to UV-C and involvement of poly (ADP-ribose) polymerase. Cell Prolif. 48:363-374. (Impact Factor: 3.28)
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  • Dwivedi M, Kemp EH, Laddha NC, Mansuri MS, Weetman AP and Begum R. (2015) Regulatory T cells in Vitiligo: Implications for pathogenesis and therapeutics. Autoimmun Rev. 14:49-56. (IF 7.1) 
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  • Vajaria BN, Patel KR, Begum R, Shah FD, Patel JB, Joshi GM, Patel PS (2014). Salivary Glyco-sialylation changes monitors Oral Carcinogensis. Glycoconjugate Journal. 31:649-59. (IF 1.9) 
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  • Mansuri MS, Singh M, Jadeja SD, Gani AR, Patel R, Dwivedi M, Laddha NC,   Ansarullah, Ramachandran AV and Begum R. (2014) Could ER Stress be a Major link between Oxidative Stress and Autoimmunity in Vitiligo?  Pigmentary Disorders 1:1-14. 
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  • Vajaria BN, Patel KR, Begum R, Shah FD, Patel JB, Joshi GM, Patel PS (2014) Clinical significance of Salivary Matrix Metalloproteinase-9 in Oral Precancerous Conditions and Oral Cancer. Cancers Review 1:33-44. 
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  • Laddha NC, Dwivedi M, Mansuri MS, Singh M, Patel HH, Agarwal N, Shah AM, and Begum R (2014). Association of Neuropeptide Y (NPY), Interleukin-1β (IL1B) Genetic Variants and Correlation of IL1B Transcript Levels with Vitiligo Susceptibility. PLoS ONE. 9:e107020. (IF 4.1)
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  • Vajaria BN, Patel KR, Begum R, Shah FD, Patel JB, Joshi GM, Patel PS (2014). Expression of Glycosyltransferases; ST3GAL1, FUT3, FUT5, and FUT6 Transcripts in Oral Cancer. Glycobiology Insights. 4:7-14. 
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  • Mansuri MS, Singh M, Dwivedi M, Laddha NC, Marfatia YS and Begum R (2014). miRNA profiling revealed differentially expressed miRNA signatures from skin of non-segmental vitiligo patients. Brit. J. Dermatol. 1:1263-7. (IF 4.2) 
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  • Begum R. (2014) Methylenetetrahydrofolate reductase (MTHFR): could it be a small piece in vitiligo jigsaw puzzle? Br J Dermatol. 170:1009-10. (IF 3.76)
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  • Laddha NC, Dwivedi M, Mansuri MS, Singh M, Gani AR, Yeola AP, Panchal VN, Khan F, Dave DJ, Patel A, Madhavan SE, Gupta R, Marfatia Z, Marfatia YS, Begum R. (2014). Role of oxidative stress and autoimmunity in onset and progression of vitiligo. Exp Dermatol. 23: 352-353.  (IF 4.1) 
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  • Rajawat J, Mir H, Alex T, Bakshi S and Begum R. (2014).  Involvement of poly(ADP-ribose)polymerase (PARP) in paraptotic cell death of D. discoideum. Apoptosis. 19:90-101. (IF 3.9) 
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  • Rajawat J, Alex T, Mir H, Kadam A Begum R. (2014). Proteases involved during oxidative stress induced poly (ADP-ribose) polymerase mediated cell death in D. discoideum. Microbiol. 160:1101-1111. (IF 2.8) 
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  • Patel KR, Vajaria BN, Begum R, Desai A, Patel JB, Shah FD, Shukla SN, Patel PS.  (2014). Prevalence of high risk human papilloma virus type 16 and 18 in oral and cervical cancers in population from Gujarat, West India. Journal of Oral Pathology and Medicine. 43: 293-7. (IF 2.055) 14. 
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  • Rajawat J, Mir H, Alex T, Bakshi S and Begum R. (2014). Involvement of poly(ADP-ribose)polymerase (PARP) in paraptotic cell death of D. discoideum. Apoptosis. 19(1):90-101. (IF 3.9)
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  • Laddha NC, Dwivedi M, Gani AR, Mansuri MS, Begum R (2013). Tumor Necrosis Factor B (TNFB) genetic variants and its increased expression are associated with vitiligo susceptibility. PLoS ONE. 8: e81736. (IF 3.73)
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  • Patel KR, Vajaria BN, Begum R, Desai A, Patel JB, Shah FD, Shukla SN, Patel PS. Prevalence of high risk human papilloma virus type 16 and 18 in oral and cervical cancers in population from Gujarat, West India. Journal of Oral Pathology and Medicine.doi: 10.1111/jop.12147 (IF 2.055)
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  • Laddha NC, Dwivedi M, Gani AR, Shajil EM, Begum R (2013). Involvement of Superoxide Dismutase Isoenzymes and their genetic variants in progression and higher susceptibility towards Vitiligo.Free Rad. Biol. & Med.65: 1110-1125.  (IF 5.271)
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  • Dwivedi M, Laddha NC, Mansuri MS, Marfatia YS and Begum R (2013). Increased NALP1 transcripts and its genetic variants correlate with disease progression and higher susceptibility towards generalized vitiligo. Brit. J. Dermatol.169:1114-1125.(IF 3.759)
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  • Dwivedi M, Laddha NC and Begum R (2013). Correlation of increased MYG1 expression and its promoter polymorphism with disease progression and higher susceptibility in vitiligo patients. J Dermatol. Sci.71: 195-202. (IF 3.718)
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  • Dwivedi M, Laddha NC, Arora P, Marfatia YS and Begum R (2013). Decreased regulatory T-Cells and CD4+/CD8+ ratio correlate with disease onset and progression in patients with generalized vitiligo. Pigment Cell Melanoma Res. 26: 586–591. (IF 5.839)
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  • Dwivedi M, Laddha NC, Shah K, Shah BJ and Begum R (2013). Involvement of Interferon-Gamma (IFNG) Genetic Variants and Intercellular Adhesion Molecule-1 (ICAM1) in Disease Onset and Progression of Generalized Vitiligo. J. Interferon Cytokine Res.33: 646-659. (IF 3.063)
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  • Laddha NC, Dwivedi M, Mansuri MS, Gani AR, AnsarullahMd, Ramachandran AV, Dalai S and Begum R (2013). Vitiligo: interplay between oxidative stress and immune system. Exp. Dermatol.22: 245-250. (IF 3.543)
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  • Birlea SA, Ahmad FJ, Uddin RM, Ahmad S, Pal SS, Begum R, Laddha NC, Dwivedi M, Mansuri MS, Jin Y, Gowan K, Riccardi SL, Holland PJ, Ben S, Fain PR and Spritz RA (2013).Association of Generalized Vitiligo with HLA Class II Loci in Patients from the Indian Subcontinent. J. Invest. Dermatol. 133:1369-72. (IF 6.314)
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  • Patel KR, Vajaria BN, Begum R, Patel PS (2013). A Review on Genetic Susceptibility towards Oral Cancer Risk among India. Gujarat Cancer Society Research Journal. 15: 10-17.
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  • Pathak A, Dwivedi M, Laddha NC, Begum R, Joshi A (2013). DNA isolation from fresh leaf tissue of Tylophoraindicaand Bacopamonnieri. International Journal of Agricultural Technology 9: 1253-1260.
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  • Pathak A, Dwivedi M, Laddha NC, Begum R, Joshi A (2013). Detection of somaclonal variants using RAPD marker in Bacopamonnieri andTylophoraindica.Enviro. Experiment. Biol.11: 69-71.
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  • Vajaria BV, Patel KR, Begum R, Shah FD, Patel JB, Shukla SN and Patel PS (2013). Evaluation of Serum and Salivary Total Sialic Acid and Alpha-L-Fucosidase in Patients with Oral Precancerous Conditions and Oral Cancer. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology.115:764-71.. (IF 1.495)
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  • Patel KR, Vajaria BN, Begum R, Shah FD, Patel JB, Shukla SN, Patel PS (2013).Association between p53 Gene Variants and Oral Cancer Susceptibility in Population from Gujarat, West India.Asian Pac J Cancer Prev., 14:1093-1100. (IF 0.66)
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  • Laddha NC, Dwivedi M and Begum R (2012). Increased Tumor Necrosis Factor (TNF)-α and its promoter polymorphisms correlate with disease progression and higher susceptibility towards vitiligo. PLoS ONE. 7: e52298. (IF 4.4)
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  • Imran M, Laddha NC, Dwivedi M, Mansuri MS, Singh J, Rani R, Gokhale RS, Sharma VK, Marfatia YSand Begum R (2012). Interleukin-4 genetic variants correlate with its transcript and protein levels in vitiligo patients. Brit. J. Dermatol. 167:314-323.(IF 4.26)
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  • Singh A, Sharma P, Kar HK, Sharma VK, Tembhre MK, Gupta S,  Laddha NC, Dwivedi M, Begum R,The Indian Genome Variation Consortium, Gokhale RS and Rani R (2012). HLA alleles and amino acid signatures of the peptide binding pockets of HLA molecules in Vitiligo. J. Invest. Dermatol. 132:124-134.(IF 6.314)
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  • Lalan MS, Laddha NC, Lalani J, Imran MJ, Begum R and Misra A (2013). Dose Reduction of a Potent Topical Corticosteroid with Microemulsion Based Cream. J Nanopharmaceutics Drug Deliv. 1: 52-63.
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  • Lalan MS, Laddha NC, Lalani J, Imran MJ, Begum R and Misra A (2012). Suppression of Cytokine Gene Expression and Improved Therapeutic Efficacy of Microemulsion Based Tacrolimus Cream for Atopic Dermatitis. Drug Deliv. Transl. Res.,2: 129-141.
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  • Vajaria BN, Patel KR, Begum R, Patel JB, Shah FD, Shukla SN, Patel PS (2012). Glycoprotein Electrophoretic Patterns have Potential to Monitor Changes Associated with Neoplastic Transformation in Oral Cancer. Int. J.Biol. Markers. 27: 247-256. (IF 1.48)
  • Mir H, Rajawat J and Begum R (2012). Staurosporine induced cell death in D. Discoideum is independent of PARP.Ind. J. Exp. Biol.50: 80-86. (IF 1.195)
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  • Ansarullah, Bharucha B, Umarani M, Dwivedi M, Laddha NC, Begum R, Hardikar AA and Ramachandran AV (2012). Oreocnideintegrifolia flavonoids augment reprogramming for islet neogenesis and ß-cell regeneration in pancreatectomized BALB/c mice. Evid Based Complement. Alternat. Med.2012:260467. (IF 4.774) 
    

h -index: 19; i-10 index: 28; citations: 879 

 
Book Chapters:
  • Dwivedi M, Laddha NC,  Weetman AP, Begum R and Kemp EH. (2015) “Vitiligo – A Complex Autoimmune Skin Depigmenting Disease”. Autoimmune Diseases. Intech- open science/open minds.
  • Shah FD, Patel JB, Begum R, Shukla SN, Patel PS and Manoharan S. (2012).  Clinical significance of glycosylation changes in oral carcinogenesis: an overview.In Oral Cancer-An Avoidable Cancer (eds) S. Manoharan (Annamalainagar, India).
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  • Begum R., Taneja TK, Mohan M., Pathak N, Sah NK, Athar M and Hasnain SE (1999). The control and execution of programmed cell death: In Recent Aspects of Fundamental and Applied Radiobiology (eds) FHA Schneeweiss and RN Sharan (Foschungszentrum, Julisch, GMBH, Germany) 30: 23-45. 
Courses being taught during 2013-2014:

Molecular Biology, Genetic Engineering & Genomics and Bio-molecules.
 
Human Genetics Practical.
 
Previously taught courses:
Molecular Biology, Genetic Engineering & Genomics, Protein Chemistry, Developmental Biology, Bioenergetics, Biostatistics and Biophysical techniques.
 
Human Genetics, Enzyme assays & purification, Microbiology, Clinical Biochemistry, Food analysis, pH & Buffers Practicals.
 
Detailed Curriculum Vitae: see downloads
 
          
Ongoing Research Projects:
 
  • Principal Investigator of DBT sponsored project entitled “Involvement of poly (ADP-ribose) polymerase in Dictyostelium discoideum development” Sanctioned amount: Rs. 19.475 lakhs.
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  • Principal Investigator of ICMR sponsored project entitled “In vitro expression studies of immune regulatory genes: significance in vitiligo pathogenesis” 2012-2015. Sanctioned amount: Rs. 34.0 lakhs.
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  • Principal Investigator of GSBTM sponsored project entitled “Identification of potential microRNAs responsible for pathogenesis of generalized vitiligo” 2011-2014. Sanctioned amount: Rs. 17.25 lakhs.
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  • Principal Investigator of DST sponsored project entitled “Role of Apoptosis Inducing Factor in Dictyostelium discoideum cell death programs” 2010-2014. Sanctioned amount: Rs. 41.52 lakhs.

 
Research Collaboration:
 
     International:
 

Dr. Richard A. Spritz, Professor and Director, Human Medical Genetics Program, University of Colorado, Denver, Aurora, CO 80045 USA.

Dr. Girish M. Shah, CRCHUQ, Laval University, Quebec City, Quebec, Canada.

 
     National:

Prof. A.V. Ramachandran, Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara -390002, Gujarat.

Dr. Yogesh S. Marfatia, Department of Skin & VD, Medical College, M. S. University of Baroda, Vadodara - 390 002, Gujarat.

Dr. Bela J. Shah, Department of Dermatology, STD and Leprosy, BJ Medical College and Civil Hospital, Hospital, Ahmedabad - 300 006, Gujarat.

Dr. Rajesh S. Gokhale, Director, Institute of Genomics and Integrative Biology, Mall Road, Delhi - 110 007.

Dr. Rajni Rani, National Institute of Immunology, ArunaAsaf Ali Marg, New Delhi - 560 012.

Dr. Shweta Saran, Jawaharlal Nehru University, New Mehrauli Road, New Delhi -110 067.

Dr. Sarat Dalai, Director, Institute of Science, Nirma University, Sarkhej-Gandhinagar Highway,  Ahmedabad 382 481.
 
 

File(s)

Prof.R.Begum_CV.pdf
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25-11-2016 16:35:23