Dr. C. Ratna Prabha

FACULTY OF SCIENCE >> Department of Bio-Chemistry
Designation : Professor
Qualification : M.Tech. (IIT, Kharagpur), Ph.D. (IIT, Mumbai)
Phone Nos : 912652795594
Email :
Experience : Date of Joining: 29/06/1998 Position: Professor
Areas of Interest : (1)Teaching: Biophysics and Biostatistics (2)Research: Protein folding and Structural biology; Proteasomes and protein degradation.
Dr. C. Ratna Prabha

Detailed CV

Name:   Dr. C. Ratna Prabha
Designation: Professor
Contact: chivukula_r@yahoo.com, +91-265-2795594
Academic background:
Ph. D. (IIT, Bombay)
M.Tech. (IIT, Kharagpur)
M. Sc. (University of Hyderabad, Hyderabad)
Professional experience:
  1. Associate Professor from June 2010 till date (M.S. University of Baroda)
  2. Reader from June 2007 to June 2010 (M.S. University of Baroda)
  3. Senior Lecturer from June 2002 to June 2007 (M.S. University of Baroda)
  4. Lecturer from June 1998 to June 2007 (M.S. University of Baroda)
  5. Temporary Lecturer from July 1997 to May 1998 (M.S. University of Baroda)
  6. BOYSCAST Fellow from March 2005 to July 2005 (Biochemistry Department, Cambridge University, Cambridge, U.K).
  7. Brain Korea –21 Fellow from October 2000  to October 2001 (Kwang-Ju Institute of Science and Technology (presently GIST), Kwang Ju, South Korea).
  8. INSA Visiting Fellow from May 2000 to June 2000 (CCMB, Hyderabad)
Research interests:
 (i) Structure function relationships in Ubiquitin
 (ii) Structure function relationships in enzymes of ubiquitination pathway
(iii) Targeted protein degradation
(iv) Thiol stress in Streptomyces coelicolor
Supervised doctoral theses and masters degrees:
  Awarded Working
Ph. D. 4 5
M. Phil. Nil Nil
M.Sc./M.Pharm/B.Tech dissertations 65 4
List of Publications:
1. C. Ratna Prabha*, S. Mukherjee, R. Raman, S. Kulkarni: The ends and means of artificially induced targeted protein degradation. Appl. Microbiol. Biotechnol., 2012, 96, 1111-1123.

2.  A. Solanki, S. B. Kumar, A. A. Doshi, C. Ratna Prabha: Mononuclear copper (II) complexes with a tetradentate pyrazole based ligand: Syntheses, structures, DNA binding study with antimicrobial activity. Polyhedron, 2013, 63, 147-155.

3.  R.N. Jadeja, Komal M. Vyas, Vivek K. Gupta, Rushikesh G. Joshi, C. Ratna Prabha: Syntheses, characterization and molecular structures of calcium(II) and copper(II) complexes bearing O2-chelate ligands: DNA binding, DNA cleavage and anti-microbial study, Polyhedron, 2012, 31, 767-778.

4. K.M. Vyas, R.G. Joshi, R.N. Jadeja, C. Ratna Prabha, V.K. Gupta: Synthesis, spectroscopic characterization and DNA nuclease activity of Cu(II) complexes derived from pyrazolone based NSO-donor Schiff base ligands, Spectrochimica Acta Part A: Molecular and Biomolecular spectroscopy, 2011, 84, 256-268.

5.   M. Sharma, C. Ratna Prabha*: construction, structural and functional characterization of double and triple mutants of parallel β-bulge of ubiquitin. Indian J Exp Biol, 2011, 49, 919-24.

6.  P. Mishra, C. Ratna Prabha*, Ch. Mohan Rao and S. Volety : Q2N and S65D Substitutions of Ubiquitin Unravel Functional Significance of the Invariant Residues Gln2 and Ser65, Cell Biochemistry and Biophysics, 2011, 61, 619-628.

7. H.J. Vekaria and C. Ratna Prabha*: Influence of thiol stress on oxidative phosphorylation and generation of ROS in Streptomyces coelicolor, J. Biophys. Chem., 2010, 1, 172-176.

8. C. Ratna Prabha* , P. Mishra and M. Shahukar : Isolation of a dosage dependent lethal mutation in ubiquitin gene of Saccharomyces cerevisiae, Macromolecular Symposia, 2010, 287, 89-94.

9. P. Mishra, S. Volety, Ch. Mohan Rao and C. Ratna Prabha*: Glutamate64 to glycine substitution in G1 β-bulge of ubiquitin impairs function and stabilizes structure of the protein, J. Biochem., 2009, 146, 563-569.

10. C. Ratna Prabha* and Ch. Mohan Rao: Oxidative refolding of lysozyme in Trifluoroethanol (TFE) and Ethylene glycol: Interfering role of preexisting a-helical structure and intermolecular hydrophobic interactions, FEBS Letters, 2004, 357, 67-72.

11. V. Acharya, C. Ratna Prabha and C.N. Murthy: Synthesis of metal incorporated low molecular weight polyurethanes from novel aromatic diols, their characterization and bactericidal properties, Biomaterials, 2004, 25, 4555-4562

12. C. Ratna Prabha, P. Rashmika and C.N. Murthy: Studies on protein- [60]fullerene interactions: the lysozyme-[60]fullerene model system, Fullerenes, Nanotubes and Carbon Nanostructures 2004, 12, 405-412.

13. V. Acharya, C. Ratna Prabha and C.N. Murthy: Synthesis and characterization of metal incorporated polyurethanes for potential bio-medical applications. J. Polymer Materials, 2003, 20, 83-90.

14. C. Ratna Prabha*: Conformational preferences of two peptides DYASL and DYA from Haemagglutinin in influenza virus and their possible role in the initiation of protein folding, Indian J. Biochem. Biophys., 2002, 39, 325-331.

15. Y.U. Sasidhar and C. Ratna Prabha:  Conformational features of reduced and disulfide intact of hen egg white lysozyme in aqueous solution in presence of 3-chloro-1,2-propanediol and dioxane: implication for protein folding intermediate. Indian J.  Biochem. Biophys., 2000, 37, 97-106.

16. C. Ratna Prabha*:  Molecular chaperones and facilitated protein folding. J.M. S. Univ., 1999-2000, 46-47, 75-86 (Review article).

17. Y.U. Sasidhar, C. Ratna Prabha and A. Gidwani: Conformational features of      certain peptides from lysozyme and their possible role in the folding of lysozyme, J. Biosciences, 24 (supplement 1), 1999, 64.

18. C. Ratnaprabha and Y.U. Sasidhar: Conformational features of disulfide  intact and reduced  forms of hen egg white  lysozyme in aqueous solution in the presence of trifluroethanol : Implications of protein folding intermediates. J. Chem. Soc. Faraday Transac., 1998, 94, 3631-3638. *- Corresponding author
Book Chapter:
H.J. Vekaria, K. Sadagopan, J. Adamec, G.K. Jarori and  C. Ratna Prabha* : Thiol stress induces catalaseA in Streptomyces coelicolor, Communicating Current Reasearch and Educational Topics and Trends in Applied Microbiology, (Ed. A. Mendez-Vilas) Formatex Research Centre, Badajoz, Spain, 2007, Vol.1, 246-255.
Courses being taught during 2013-2014:
Structural Biology, Biophysical techniques, Biostatistics, Protein structure
Protein purification (Practical), Protein folding (Practical)
Previously taught courses:
Amino acid metabolism, Molecular biology
Molecular Biology (Practical)
Any other relevant information:
Ongoing Research Projects:
  1. Principal Investigator of BRNS sponsored project entitledStructure-function studies of ubiquitin and ubiquitin activating enzyme (E1) 2014-2017 Sanctioned amount: Rs. 33.75 lakhs. 
  2. Principal Investigator of CSIR sponsored project entitled Studies on the Effects of Mutations in Parallel β-bulge of Ubiquitin on Protein Translation, Sorting and Lysosomal Degradation 2013-2016. Sanctioned amount: Rs. 34.0 lakhs.
Conferences organized
            Convener for ‘CME in Immunology’ organized by Department of Biochemistry, The M. S.   University of Baroda on 27&28 November 2009, sponsored by GSBTM, UGC, MCI and      ICMR.
Invited Talks:
  1. Structural Alterations of Ubiquitin Reveal Functional Significance of the Residues and Rationale for Their Evolutionary Conservation” in the Department of Chemistry, IIT Bombay, Mumbai on 24th February 2011
  2. “Proteomics” in UGC sponsored Winter School in Bioinorganic Chemistry (WiSBiC) UGC-CAS 5 day School from 8-12 March 2011, organized by the M. S. University of Baroda, vadodara (as resource person).
  3. “Calcium metabolism” in UGC sponsored Winter School in Bioinorganic Chemistry (WiSBiC) UGC-CAS 5 day School from 8-12 March 2011 organized by the M. S. University of Baroda, Vadodara (as resource person).
Awards, Fellowships and Scholarships:
(i)  BOYSCAST Fellowship (March 2005- July 2005)               
(ii) Brain Korea –21 Fellowship (Oct 2000- Oct 2001)               
(iii) INSA Visiting Fellowship (May 2000-June 2000)               
(iv) CSIR Fellowship: of CSIR-UGC (UGC-NET) examination in 1988.
(v) GATE-86 Fellowship from June 1986 to January 1988.        
(vi) Placed first in the class in M. Tech. (Biotechnology & Engg.)          
(vii) Travel award from INSA and CSIR for attending MAM 08 in Dusseldorf, Germany
(viii) Travel award from DST for attending IWFAC in St. Petersberg, Russia
(xi) Travel award from DST and INSA for attending ‘Cell Biology of Yeasts’ meeting organized by Cold Spring Harbor Laboratory in New York, USA


25-11-2016 17:29:52